NAME
mssstest - Normalisationo of disease scores - originally developed for
the EDSS for Multiple Sclerosis
SYNOPSIS
mssstest
DESCRIPTION
Suppose one is interested in determining whether the genotype at some
locus of interest affects the rate of progression of disease of people
with Multiple Sclerosis (MS). One method would be to calculate the mean
EDSS score in patients with each of the genotypes and test whether they
are significantly different. However, this approach is inefficient if
patients have their EDSS assessed at different durations of disease, as
patients who have had MS longer typically have higher EDSS scores
regardless of their genotype. By adjusting for duration, a more
powerful test can be developed.
MSSStest is a program for implementing the method described in the
article The Multiple Sclerosis Severity Score. R. Roxburgh S. Seaman et
al. (2004), accepted for publication by Neurology. It calculates MSSS
scores and uses these scores to test for differences between disease
progression rates in different groups defined by genotype at some
locus.
To use the program first copy the table of disease scores to the
current directory. You are expected to use the EDSS scores provided by
the authors.
OPTIONS
The program does not accept options, it should, though. The output goes
to the files "msss.out" and "indivmsss.out".
SEE ALSO
http://www-gene.cimr.cam.ac.uk/MSgenetics/GAMES/MSSS/#top
/usr/share/doc/mssstest/README.gz
AUTHOR
mssstest was written by Shaun Seaman and Richard Roxburgh
<Richard@Roxburgh.net.nz>.
This manual page was written by Steffen Moeller <moeller@pzr.uni-
rostock.de>, for the Debian project (but may be used by others).
November 30, 2004